SH-POLYPEPTIDE-42 is graded A (Safe) by Expert·ING, based on COSING regulatory data.

SH-POLYPEPTIDE-42

Safety grade: A

This is a lab-created protein fragment made up of amino acids (the building blocks of proteins) designed to improve skin health. It works by mimicking natural proteins found in skin to help restore its structure and appearance.

This ingredient conditions and strengthens the skin by helping to maintain its natural barrier function, improve elasticity, and promote a smoother, more hydrated complexion.

Graded using: COSING.

Last verified: May 26, 2026

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