HEXAPEPTIDE-4 is graded A (Safe) by Expert·ING, based on COSING, FDA regulatory data.

HEXAPEPTIDE-4

Safety grade: A

Hexapeptide-4 is a short chain of six amino acids (the building blocks of proteins) that is designed to help improve skin texture and firmness. It works by signaling skin cells to produce more collagen and elastin, the proteins responsible for keeping skin smooth and elastic.

This ingredient is used in skincare products to condition and improve skin appearance by promoting natural protein production, helping to reduce the appearance of fine lines and enhance skin firmness and smoothness.

Graded using: COSING, FDA.

Last verified: May 26, 2026