PENTAPEPTIDE-81 is graded A (Safe) by Expert·ING, based on COSING regulatory data.

PENTAPEPTIDE-81

Safety grade: A

This lab-created ingredient is a short chain of amino acids designed to help skin look firmer and more youthful. It works by signaling skin cells to boost collagen production, which naturally decreases with age. You'll typically find it in anti-aging serums and moisturizers.

Graded using: COSING.

Last verified: June 9, 2026