4-NITRO-O-PHENYLENEDIAMINE is graded C (Moderate) by Expert·ING, based on COSING regulatory data. It is restricted under EU COSING — AnnexIII-SAFETY-.
4-NITRO-O-PHENYLENEDIAMINE
Safety grade: C
This is a synthetic chemical compound used in hair dye formulations to create color. It belongs to a family of dye molecules that react with other chemicals to produce lasting color in hair.
It is used in hair coloring products as a dye intermediate, helping to create and deposit color onto hair strands for long-lasting results.
Graded using: COSING.
- EU COSING — Restricted
Last verified: May 26, 2026
Safer alternatives to 4-NITRO-O-PHENYLENEDIAMINE
- 2-METHOXYMETHYL-P-PHENYLENEDIAMINE — Grade A. Direct substitute: aromatic diamine dye intermediate for permanent hair color
- 5-AMINO-6-CHLORO-O-CRESOL — Grade A. Aromatic amine compound used as oxidative hair dye intermediate
- LAWSONIA INERMIS EXTRACT — Grade A. Natural plant extract providing permanent hair coloring via oxidative coupling
Other Hair Dyeing ingredients
- RESORCINOL — Grade E**
- THYMOL — Grade A
- M-AMINOPHENOL — Grade C**
- P-AMINOPHENOL — Grade C**
- 2-METHYLRESORCINOL — Grade C
- 4-AMINO-2-HYDROXYTOLUENE — Grade C
- P-PHENYLENEDIAMINE — Grade D**
- 2-METHYL-5-HYDROXYETHYLAMINOPHENOL — Grade C